Table 2.
Selected variables by multivariable cox regression analysis.
| Variable | Multivariable analysis | ||
|---|---|---|---|
| HR | 95% CI | p-value | |
| Age of diagnosis | 1.032 | [1.026, 1.036] | p ≤ 0.001∗∗∗ |
| Sex | |||
| Male | Reference | ||
| Female | 0.886 | [0.793, 0.990] | 0.033 ∗ |
| Race | |||
| White | Reference | ||
| Black | 1.238 | [1.021, 1.501] | 0.030 ∗ |
| Other | 1.144 | [0.953, 1.372] | 0.148 |
| Marital status | |||
| Married | Reference | ||
| Single | 1.553 | [1.357, 1.777] | p ≤ 0.001∗∗∗ |
| Other | 1.353 | [1.194, 1.534] | p ≤ 0.001∗∗∗ |
| Size | |||
| ≤2 | Reference | ||
| [2, 4] | 1.346 | [1.118, 1.620] | p ≤ 0.001∗∗ |
| ≥4 | 1.768 | [1.486, 2.104] | p ≤ 0.001∗∗∗ |
| AJCC stage | |||
| I | Reference | ||
| II | 1.348 | [1.058, 1.718] | 0.015 ∗ |
| III | 1.379 | [1.043, 1.823] | 0.023 ∗ |
| IV | 1.586 | [1.171, 2.148] | 0.003 ∗∗ |
| Combined summary stage | |||
| Localized | Reference | ||
| Regional | 1.342 | [1.082, 1.666] | 0.007 ∗∗ |
| Distant | 1.951 | [1.501, 2.536] | p ≤ 0.001∗∗∗ |
| Surgery | |||
| Yes | Reference | ||
| No/unknown | 1.150 | [0.930, 1.422] | 0.195 |
| Radiotherapy | |||
| Yes | Reference | ||
| No/unknown | 1.543 | [1.240, 1.921] | p ≤ 0.001∗∗∗ |
| Chemotherapy | |||
| Yes | Reference | ||
| No/unknown | 1.111 | [0.958, 1.288] | 0.162 |
| RX summ—scope reg LN sur | |||
| Yes | Reference | ||
| No/unknown | 1.196 | [1.043, 1.371] | 0.010 ∗ |
| RX summ—surg/rad seq | |||
| No radiation | Reference | ||
| Radiation prior to surgery | 0.988 | [0.605, 1.615] | 0.964 |
| Radiation after surgery | 1.185 | [0.957, 1.468] | 0.117 |
| Radiation before and after surgery | 2.429 | [1.468, 4.019] | p ≤ 0.001∗∗∗ |
| Income | |||
| <$55,000 | Reference | ||
| [$55,000, $75,000] | 1.020 | [0.890, 1.169] | 0.773 |
| >$75,000 | 0.945 | [0.813, 1.100] | 0.470 |
Notes. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p ≤ 0.001, HR: hazard ratio, CI: confidence interval, RX summ—scope reg LN sur: regional lymph node dissection after surgery; RX summ—surg/rad seq: surgery and radiation sequence.