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. 2022 Apr 28;30(1):62–73. doi: 10.1007/s12350-022-02968-9

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Two-tissue compartment model for ¹⁸F-flurpiridaz in the mouse myocardium. (A) Visualization of the model. While K₁ and k₂ describe tracer delivery to the myocardium and clearance from the myocardium, respectively, k₃ and k₄ represent the association and dissociation rate constants toward mitochondrial complex I (MC-I), which is located at the mitochondrial membrane of cardiomyocytes. (B) Representative two-tissue compartment fitting for the assessment of K₁ and tissue volume of distribution (V_T). (C) Representative logan graphical analysis