Table 2.

Assessment of logistic regression and random forest biomarker models in the confirmatory and replication cohorts

Method	Biomarkers/Models	AUC of confirmatory cohort between NDO vs. DO	AUC of replication cohort between NDO vs. DO
Logistic regression	FBP1 + GSTA1	0.75	0.69
	FBP1 + GSTA1 + LECT2	0.78	0.68
	FBP1 + CES1 + LECT2	0.78	0.64
Random forest	FBP1 + LECT2	1.00	0.64
	FBP1 + LECT2 + CPS1	1.00	0.61

AUC area under the receiver operating characteristic curve, NDO non-DILI patients at onset, DO DILI patients at onset. See also Supplementary Fig. 5.