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. 2022 Oct 5;30(3):673–686. doi: 10.1038/s41418-022-01071-3

Fig. 3. Hsp90ab1 deletion improves ovariectomy-induced bone loss by inhibiting osteoclast activity.

Fig. 3

A Schematic for ovariectomy-induced bone loss mice model. B Body weight after OVX was recorded for 15 weeks. C–E Serum CTX-1, ALP and calcium concentration in myeloid Hsp90ab1 knockout mice (n = 6). F Representative reconstructed 3D μCT images of proximal tibia in myeloid Hsp90ab1 knockout mice (n = 6). G–L Quantification of BMD, Conn.D, Tb.Th, Tb.N, BV/TV and Tb.Sp from μCT images. M H&E and TRAP staining of the femora from OVX-mice (black arrows, TRAP-positive cells). Scale bars, 500 μm and 100 μm. Bars represent means ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001.