Table 3.
The AKT inhibitory activity of synthesized compounds
Comp. code | IC50 (μM)a |
---|---|
7e | 15.32 ± 0.66 |
7f | 6.90 ± 0.23 |
7g | 12.94 ± 0.28 |
8d | 11.96 ± 0.02 |
8e | 10.35 ± 0.12 |
8f | 5.38 ± 0.13 |
8g | 8.39 ± 0.05 |
2b | 0.10 ± 0.62 |
aThe values are the mean ± SD of at least three independent experiments
bCompound 2 = reference standard