Fig. 5.

Effects of P2Y1R agonists and antagonists on social isolation–caused depressive- and anxiety-like behavioral deficits. a Changes in the SPT of SI mice after treated with MRS2179 or MRS2365. b Changes in the TST of SI mice after treated with MRS2179 or MRS2365. c Moving trajectory diagram in the OFT. d Changes of total distance of motor activity in the OFT of SI mice after treated with MRS2179 or MRS2365. e Changes of spent time in the center zone in the OFT of SI mice after treated with MRS2179 or MRS2365. The data were expressed as mean ± SEM (n = 5). ^#P < 0.05, SI + 2179 group versus SI group. SI social isolated, SPT sucrose preference test, TST tail suspension test, OFT open field test