Fig. 7.

EA attenuated social isolation–caused depressive- and anxiety-like behavioral deficits and P2Y1R agonists reversed the antidepressant effects of EA. a Changes of sucrose preference percentage in the SPT of five groups on PND94: GH, SI, EA, SEA, and EA + 2365 groups. b Changes of immobility time in the TST of five groups on PND94: GH, SI, EA, SEA, and EA + 2365 groups. c Moving trajectory diagram in the OFT. d Changes of distance of motor activity in the OFT of five groups on PND94: GH, SI, EA, SEA, and EA + 2365 groups. e Changes of spent time in the center zone in the OFT of five groups on PND94: GH, SI, EA, SEA, and EA + 2365 groups. The data were expressed as mean ± SEM (n = 6). *P < 0.05, EA group versus SI group. ^#P < 0.05, EA + 2365 group versus EA group. EA electroacupuncture, GH group housed, OFT open field test, SI social isolated, SPT sucrose preference test, SEA sham electroacupuncture, TST tail suspension test