Table 2.
SNP | Genetic model | Genotype/allele | Cases | Controls | OR | 95% CI | p value |
---|---|---|---|---|---|---|---|
rs1491974 | Codominant | AA vs. AG vs. GG | 27 (15.3%)/88 (50.0%)/61 (34.7%) | 14 (28.0%)/26 (52.0%)/10 (20.0%) | - | - | 0.047* |
Allele contrast | A vs. G | 142 (40.3%)/210 (59.7%) | 54 (54.0%)/46 (46.0%) | 0.576 | 0.368–0.901 | 0.015* | |
Dominant | GG vs. AG+AA | 61 (34.7%)/115 (65.3%) | 10 (20.0%)/40 (80.0%) | 2.122 | 0.993–4.534 | 0.049* | |
Recessive | AG+GG vs. AA | 149 (84.7%)/27 (15.3%) | 36 (72.0%)/14 (28.0%) | 2.146 | 1.023–4.503 | 0.040* | |
Overdominant | AA+GG vs. AG | 88 (50.0%)/88 (50.0%) | 24 (48.0%)/26 (52.0%) | 1.083 | 0.578–2.031 | 0.803 | |
rs6798347 | Codominant | AA vs. AG vs. GG | 7 (4.0%)/61 (34.6%)/108 (61.4%) | 6 (12.0%)/19 (38.0%)/25 (50.0%) | - | - | 0.069 |
Allele contrast | A vs. G | 75 (21.3%)/277 (78.7%) | 31 (31.0%)/69 (69.0%) | 0.603 | 0.367–0.988 | 0.043* | |
Dominant | GG vs. AG+AA | 108 (61.4%)/68 (38.6%) | 25 (50.0%)/25 (50.0%) | 1.588 | 0.844–2.988 | 0.150 | |
Recessive | AG+GG vs. AA | 169 (96.0%)/7 (4.0%) | 44 (88.0%)/6 (12.0%) | 3.292 | 1.053–10.292 | 0.032* | |
Overdominant | AA+GG vs. AG | 115 (65.4%)/61 (34.6%) | 31 (62.0%)/19 (38.0%) | 1.155 | 0.603–2.213 | 0.663 |
CI, confidence interval; OR, odds ratio
*p<0.05