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. 2022 Oct 12;77(6):1968–1982. doi: 10.1002/hep.32776

FIGURE 4.

FIGURE 4

IL‐18 signaling and downstream regulatory network are activated in CDAA‐HFD–induced fibrotic NASH. Bulk RNA sequencing analysis of liver tissue after 10 weeks of CDAA‐HFD or CD. (A) An overview of experimental design. (B) Clustering of IL‐18 signaling‐related gene transcripts. (C) Clustering of fibrosis‐related gene transcripts. CD, control diet; CDAA‐HFD, choline‐deficient, L‐amino acid‐defined high fat diet. n = 4 mice per group.