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(A) Low power view of a biopsy specimen from the wrist shows irregular acanthosis and full-thickness dysplasia of the epidermis without infiltration of atypical cells into the dermis. (Hematoxylin & eosin, ×100). (B) Higher magnification shows the epidermis with hyperchromatic nuclei, atypia, and numerous mitoses. (Hematoxylin & eosin, ×200).
