Table 3.

Decellularized fish skin with their origin and effectivity.

Decellularized materials	Authors, Year, Country	Study Design	sources of materials	Results	Conclusion
Decellularized fish skin	Mauer ES et al. [167],v 2021, USA	Clinical study	fish skin	Wounds closed by second-intention healing following the first fish skin application between 26 and 145 days. In cats, 1 or 2 FSGs were used, and the wounds of 3 of 4 cats healed completely by secondary intention. The wounds of 1 dog and 1 cat did not heal.	The main limitation of the present case series was the small sample size and retrospective nature of the study, with various wound management techniques used.
Decellularized fish skin	Dorweiler B et al. [168],v 2018, Germany	Clinical study	fish skin	In total 25 wounds were treated with localization at the level of the thigh (n ​= ​2), the distal calf (n ​= ​7), the forefoot (n ​= ​14) and the hand (n ​= ​2). The time to heal varied between 9 and 41 weeks and between 3 and 26 wound matrices were applied per wound. Interestingly, a reduction of analgesics intake was noted when the treatment with the Omega3 Wound matrix was initiated.	The novel Omega3 Wound matrix in this study represented an effective treatment option in 25 complicated wounds. Further studies are necessary to evaluate the impact of the wound matrix on stimulation of granulation tissue and re-epithelialization as well as the potential antinociceptive and analgetic effects.
Decellularized fish skin	Badois N et al. [169], 2019, France	Clinical study	fish skin	There were 21 patients included. The healing time was halved when using the acellular fish skin matrix, from 68 to 32 days on average. Acellular fish skin matrix reduced pain levels and local infection. The visual analogue pain scale (VAS) was ≥3 ​at five days and infection rate reduced from 60% to 0%.	A larger study including an overall cost estimation and an assessment on different wound types would be interesting, to better target the indications of the acellular fish skin matrix.