Table 5.

Other decellularized biomaterials with their origin and effectivity.

Decellularized materials	Authors, Year, Country	Study Design	sources of materials	Results	Conclusion
decellularized small intestine submucosa matrix	Moon SukKim et al. [185], 2005, Korea	Development and characterization study		The SIS sponges absorbed higher extent of exudation for wound than that covered with control. The dermal collagen in the wound regenerated at only SIS sponges treated wounds. The progress of granulous tissue formation was faster in SIS sponges.	The SIS sponges might be a potential material as a wound dressing
decellularized small intestine submucosa matrix	Fan MR et al. [183], 2014, China	Development and characterization study	porcine small intestinal submucosa	The release of VEGF and TGF-β gradually increased with time. The three-dimensional microarchitecture of SIS surface seems to be in favor of cell adherence, growth and migration.	The scaffold exhibited a porous nature and three-dimensional microarchitecture on its surface, which may facilitate cell adherence and growth. Furthermore, it also possesses the crucial bio inductive property owing to release.
decellularized small intestine submucosa matrix	Sarikaya A et al. [184], 2002, USA.	Development and characterization study	porcine small intestinal submucosa	DSIS and UBM contained antibacterial activity against both Gram-positive and Gram-negative bacteria.	porcine SIS discourages bacterial growth.
decellularized small intestine submucosa matrix	Guo X et al. [187], 2016, China	Development and characterization study	porcine small intestinal submucosa	SIS alone and MSC-seeded SIS were able to accelerate the burn wound closure by enhancing granulation tissue formation, increasing wound maturity, improving revascularization, and inducing the proliferation of neo-epidermal cells.	SIS and MSC-seeded SIS were able to repair the large and deep burn wounds and possessed positive effects to accelerate the wound closure in a rat model.
decellularized small intestine submucosa matrix	Rashtbar M et al. [188], 2018, Iran	Development and characterization study	ovine small intestinal submucosal	In DSIS with BMSCs group, epithelization was fast and had fully taken place at the subsequent time points. DSIS layer, as cell-free form with low substantially DNA content, accelerated healing of rat skin wound defects that was created at critical-size and full-thickness.	DSIS alone and in combination with BM-MSCs has the potential to be used as a wound graft material in skin regenerative medicine.
decellularized small intestine submucosa matrix	Parmaksiz M et al. [189], 2017, Turkey	Development and characterization study	ovine small intestinal submucosal	MSCs can preserve their viability and proliferate on DSIS for >2 weeks in culture. The wound models treated with DSIS membranes were completely closed by week 7 without significant differences in closure time; the open wound control was closed at ∼47% at this time point. The DSIS had less scarring at the end of the healing process.	DSIS membranes could be used as a suitable regenerative biomaterial, alone or as a scaffold material, to transplant MSCs in tissue engineering applications. Particularly, DSIS membranes accelerate healing of critical-sized, full thickness rat skin wound defects.
Decellularized Urinary Bladder Extracellular Matrix	Alvarez OM et al. [215], 2017, USA	Clinical study	porcine urinary bladder	In the UBM group, the incidence of wound healing at 12 and 16 weeks was 90% and 100%, respectively, compared with 33% and 83.3% in the control. The mean time to healing in the UBM-treated group was 62.4 days compared with 92.8 days in the control group.	Treatment of DFUs with a UBM could significantly reduce the healing time and reduce the rate of recurrence.
Decellularized Urinary Bladder Extracellular Matrix	Paige JT et al. [217], 2019, Korea	Development and characterization study	porcine urinary bladder	Wound tissue from diabetic subjects exhibited elevated M1:M2 scores compared with nondiabetic patients, suggesting a greater pro-inflammatory state prior to treatment.	UBM may assist in diabetic wound healing by restoring an inflammatory state similar to that of nondiabetic patients.