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Histone malonylation as a function of age
(A) Western blot of protein samples prepared from young (2 months old) and middle-aged (18 months old) female C57BL/6 mouse brains.
(B) Quantification of the ODs of blots. n = 3 per group. Error bar: mean ± SD, ∗p < 0.05, ∗∗p < 0.01 with unpaired Student’s t test.
(C) Schematic of histone malonylation regulated by malonyl-CoA level, KAT2A, and SIRT5 emerges as a mechanistic link connecting metabolism, gene expression, and aging.
