a, The RNA-Seq data of the primary visual cortex from an Alzheimer disease female. b, The RNA-Seq data of a control male precuneus. In (a) and (b), the green bars pointed by red arrows are duplication like read-pair signatures, i.e., there are 4 supporting discordant read-pairs in (a), and 2 in (b). Moreover, read depth change (fitted by purple line) on exon is observed in both (a) and (b). The RNA-Seq data for (a) and (b) are obtained from Sequence Read Archive (SRA) with accession number SRR14194220 and SRR14194206, respectively.