Table 1.
Exosomal miRNAs as biomarkers for AD.
| Study | Source | Down-regulated miRNAs | Up-regulated miRNAs | Known target genes (relevant to AD pathogenesis) |
|---|---|---|---|---|
| Riancho et al., 2017 | CSF | miR-9-5p | ||
| CSF | miR-16-2 | |||
| McKeever et al., 2018 | CSF | miR-16-5p | ADAM10; APH1A; APP; MME; CDK5R1 | |
| Gui et al., 2015 | CSF | miR-29c | BACE1; GAPDH; LPL; CASP7; GSK3β | |
| McKeever et al., 2018 | CSF | miR-125-5p | APP | |
| Gui et al., 2015 | CSF | miR-132-5p | ||
| McKeever et al., 2018 | CSF | miR-125b-5p | ||
| Gui et al., 2015 | CSF | miR-136-3p | ||
| Liu et al., 2014 | CSF | miR-193b | ||
| Gui et al., 2015 | CSF | miR-331-5p | ||
| McKeever et al., 2018 | CSF | miR-451a | ||
| Gui et al., 2015 | CSF | miR-485-5p | ||
| Riancho et al., 2017 | CSF | miR-598 | ||
| McKeever et al., 2018 | CSF | miR-605-5p | ||
| Nie et al., 2020 | Plasma | let-7e-5p | ||
| Gámez-Valero et al., 2019 | Plasma | let-7i-5p | APH1A; IDE; LRP1; CASP3 | |
| Nie et al., 2020 Serpente et al., 2020 Gámez-Valero et al., 2019 | Plasma | miR-23a-3p | miR-23a-3p | ADAM10; PSEN1; NCSTN; APH1A; CASP3; CASP7 |
| Lugli et al., 2015 | Plasma | miR-23b-3p | ADAM10; APH1A; GAPDH; NCSTN; PSEN1; ASP3; CASP7 | |
| Lugli et al., 2015 | Plasma | miR-24-3p | APH1A; NCSTN; CAPN1; GSK3β | |
| Lugli et al., 2015 | Plasma | miR-29b-3p | BACE1; GAPDH; LPL; CASP7; GSK3β | |
| Serpente et al., 2020 | Plasma | miR-100-3p | ||
| Nie et al., 2020 | Plasma | miR-125a-5p | ||
| Lugli et al., 2015 | Plasma | miR-125b-5p | APP | |
| Gámez-Valero et al., 2019 | Plasma | miR-126-3p | CAPN1 | |
| Cha et al., 2019 | Plasma | miR-132 | APH1A; CAPN2; CASP7; GSK3β | |
| Lugli et al., 2015 | Plasma | miR-138-5p | ||
| Lugli et al., 2015 | Plasma | miR-139-5p | ||
| Lugli et al., 2015 | Plasma | miR-141-3p | APH1B; GAPDH; PSEN1 | |
| Lugli et al., 2015 | Plasma | miR-150-5p | ||
| Gámez-Valero et al., 2019 | Plasma | miR-151a-3p | GAPDH; APH1A | |
| Lugli et al., 2015 | Plasma | miR-152-3p | ||
| Lugli et al., 2015 | Plasma | miR-185-5p | BACE2; GAPDH; LPL; MME; GSK3β | |
| Serpente et al., 2020 | Plasma | miR-190a-5p | ||
| Nie et al., 2020 | Plasma | miR-204-5p | ||
| Cha et al., 2019 | Plasma | miR-212 | CAPN2; GSK3β | |
| Serpente et al., 2020 | Plasma | miR-223-3p | ||
| Lugli et al., 2015 | Plasma | miR-338-3p | ||
| Lugli et al., 2015 | Plasma | miR-342-3p | APH1B; MME; LPL; GSK3β | |
| Lugli et al., 2015 | Plasma | miR-342-5p | GAPDH; LRP1 | |
| Nie et al., 2020 | Plasma | miR-369-5p | ||
| Nie et al., 2020 | Plasma | miR-375 | ||
| Nie et al., 2020 | Plasma | miR-423-5p | ||
| Lugli et al., 2015 | Plasma | miR-659-5p | ||
| Nie et al., 2020 | Plasma | miR-1468-5p | ||
| Lugli et al., 2015 | Plasma | miR-3065-5p | ||
| Lugli et al., 2015 | Plasma | miR-3613-3p | ||
| Lugli et al., 2015 | Plasma | miR-3916 | ||
| Lugli et al., 2015 | Plasma | miR-4772-3p | ||
| Lugli et al., 2015 | Plasma | miR-5001-3p | ||
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-15a-5p | ADAM10; APH1A; APP; BACE1; MME; CDK5R1 | |
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-15b-3p | ||
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-18b-5p | APH1B; GAPDH | |
| Cheng et al., 2020 Li et al., 2020 Cheng et al., 2015 | Serum | miR-20a-5p | APP | |
| Barbagallo et al., 2020 | Serum | miR-29a | APH1A; GAPDH; BACE1; BACE2; LPL; GSK3β; CASP7 | |
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-30e-5p | APP; NAE1; CASP3 | |
| Cheng et al., 2020 | Serum | miR-32-5p | ||
| Barbagallo et al., 2020 | Serum | miR-34b | ||
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-93-5p | APP; GAPDH; LRP1; GSK3β | |
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-101-3p | ADAM10; APP; PSEN1; CAPN2; CASP3; GSK3β | |
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-106a-5p | APP; ADAM17; CAPN2 | |
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-106b-5p | APP; CASP7 | |
| Yang et al., 2018c | Serum | miR-135a | ||
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-143-3p | ADAM10; LRP1 | |
| Yang et al., 2018c | Serum | miR-193b | ||
| Cheng et al., 2020 | Serum | miR-219a | ||
| Wei et al., 2018 | Serum | miR-223 | ||
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-335-5p | APBB1; LRP1; CASP7 | |
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-342-3p | APH1B; MME; LPL; GSK3β | |
| Li et al., 2020 (Cheng et al., 2015) | Serum | miR-361-5p | ADAM10; APH1B; LRP1 | |
| Cheng et al., 2020 | Serum | miR-374a-5p | ||
| Yang et al., 2018c | Serum | miR-384 | ||
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-424-5p | APBB1; APH1A; APP; LRP1; CDK5R1; GSK3β | |
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-582-5p | IDE | |
| Cheng et al., 2020 | Serum | miR-585-5p | ||
| Cheng et al., 2020 | Serum | miR-941 | ||
| Li et al., 2020 Cheng et al., 2015 | Serum | miR-1306-5p | ||
| Cheng et al., 2020 Li et al., 2020 Cheng et al., 2015 | Serum | miR-3065-5p | ||
| Cheng et al., 2020 | Serum | miR-3157-5p |