Table 2.
Baseline characteristics of animals receiving placebo or cell therapy with umbilical cord tissue-derived mesenchymal stromal cells (UC-MSC).
| Placebo (n = 5) | UC-MSC (n = 8) | |
|---|---|---|
| Phenotypical characteristics: no. (%) | ||
| Papio anubis × Papio cynocephalus | 3 (60) | 5 (63) |
| Female | 3 (60) | 5 (63) |
| Singletons | 5 (100) | 8 (100) |
| Perinatal characteristics: no. (%) | ||
| Complicated pregnancy course* | 0 (0) | 0 (0) |
| Complete RDS-prophylaxis | 5 (100) | 7 (88) |
| Perinatal characteristics: mean (range) | ||
| Gestational age at birth [day] | 126 (125-127) | 126 (124-128) |
| Birth weight [g] | 367 (326-386) | 372 (332-404) |
| Baseline vital parameters: mean (CI95%)† | ||
| SpO2 [%] | 91 (86-97) | 92 (89-96) |
| FiO2 | 0.40 (0.21-0.64) | 0.29 (0.21-0.37) |
| Mean airway pressure [cmH2O] | 12.0 (11.8-12.2) | 11.6 (11.1-12.1) |
| Mean arterial blood pressure [mmHg] | 36 (35-37) | 31 (25-37) |
| Heart rate [min−1] | 169 (160-178) | 171 (158-184) |
*Infections, gestational diabetes, vaginal bleeding, or discordant growth of the fetus.
†Averaged over 60 minutes prior to administration of MSC or placebo. No significant (P < .05) differences between groups for any of the parameters by Fisher’s exact or Welch’s unequal variance t-test. Abbreviations: RDS, respiratory distress syndrome; CI95%, 95% confidence interval of the mean; SpO2, peripheral oxygen saturation; FiO2, fraction of inspired oxygen.