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. 2023 Mar 2;12(2):112–122. doi: 10.1093/stcltm/szad003

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — IFN-γ priming of MSCs neutralizes baseline transcriptomic differences and induces shared gene expression pathways. (A): Principal component analyses of MSCs after IFN-γ priming for Ctrl (n = 6), CD (n = 5) and UC (n = 7) patients based on age, sex (male or female), tissue site (ileum or rectum), disease condition (control, CD, or UC), and inflammation status (inflamed or uninflamed). Number of common and unique IFN-γ induced genes expressed for Ctrl, CD, and UC MSCs in the (B) ileum and (C) rectum. Volcano plot of differentially expressed genes of in (D) ileal CD and (E) rectal UC MSCs relative to Ctrl MSCs with IBD-associated genes highlighted.