Table 5.
The top GREAT ontology enrichments for regions potentially related to systolic blood pressure
| Ontology database | Term name | Binom FDR Q-value | Binom region fold enrichment |
|---|---|---|---|
| PANTHER pathway | Cytoskeletal regulation by Rho GTPase | 1.29E-17 | 2.19 |
| PANTHER pathway | Nicotinic acetylcholine receptor signaling pathway | 8.79E-14 | 1.83 |
| PANTHER pathway | Metabotropic glutamate receptor group II pathway | 5.05E-11 | 2.01 |
| PANTHER pathway | GABA-B receptor II signaling | 2.71E-10 | 1.97 |
| PANTHER pathway | p53 pathway by glucose deprivation | 6.02E-09 | 2.57 |
| PANTHER pathway | Angiogenesis | 1.50E-07 | 1.35 |
| PANTHER pathway | Inflammation mediated by chemokine and cytokine signaling pathway | 2.66E-07 | 1.37 |
| PANTHER pathway | Endogenous cannabinoid signaling | 2.98E-07 | 2.05 |
| PANTHER pathway | Notch signaling pathway | 6.81E-07 | 1.78 |
| PANTHER pathway | Hedgehog signaling pathway | 4.77E-06 | 1.94 |
| PANTHER pathway | Thyrotropin-releasing hormone receptor signaling pathway | 7.80E-06 | 1.54 |
| PANTHER pathway | Gamma-aminobutyric acid synthesis | 8.53E-06 | 3.62 |
| PANTHER pathway | Nicotine pharmacodynamics pathway | 1.43E-05 | 1.82 |
| PANTHER pathway | Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | 5.11E-05 | 1.74 |
| PANTHER pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha-mediated pathway | 7.86E-05 | 1.29 |
| PANTHER pathway | Corticotropin-releasing factor receptor signaling pathway | 7.85E-04 | 1.68 |
| PANTHER pathway | Adrenaline and noradrenaline biosynthesis | 2.65E-03 | 1.67 |
| PANTHER pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | 5.49E-03 | 1.42 |
| PANTHER pathway | PI3 kinase pathway | 1.32E-02 | 1.34 |
| PANTHER pathway | Histamine H1 receptor-mediated signaling pathway | 1.97E-02 | 1.33 |
| MSigDB pathway | Focal adhesion | 1.43E-17 | 1.51 |
| MSigDB pathway | Type II diabetes mellitus | 2.42E-14 | 1.95 |
| MSigDB pathway | Taurine and hypotaurine metabolism | 8.37E-13 | 3.96 |
| MSigDB pathway | RAC1 signaling pathway | 1.00E-12 | 2.05 |
| MSigDB pathway | Insulin signaling pathway | 8.51E-10 | 1.49 |
| MSigDB pathway | Regulation of RhoA activity | 6.87E-09 | 1.82 |
| MSigDB pathway | Arachidonic acid metabolism | 7.32E-08 | 2.01 |
| MSigDB pathway | T cell receptor signaling pathway | 8.83E-06 | 1.39 |
| MSigDB pathway | mTOR signaling pathway | 7.31E-05 | 1.53 |
| MSigDB pathway | VEGF signaling pathway | 5.69E-04 | 1.42 |