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. 2023 Mar 3;15:14. doi: 10.1186/s13073-023-01164-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — scRNA-seq analysis of NSCLC during therapy. A Scheme of the overall study design. B Uniform manifold approximation and projection (UMAP) plot of all cells colored by major cell types according to canonical markers. C Bar plots indicating the proportion of major cell lineages in each patient. D Boxplot showing cellular fractions of T, natural killer (NK), B, myeloid cells and neutrophils in TN (n = 3), MPR (n = 4), and NMPR (n = 8) patients. Center line indicates the median value, lower and upper hinges represent the 25th and 75th percentiles, respectively, and whiskers denote 1.5× interquartile range. Each dot corresponds to one sample. All adjusted P values were larger than 0.05. One-sided unpaired Wilcoxon test was used, and the P values were adjusted by the FDR method. E Representative images of immunohistochemistry (IHC) staining of canonical surface markers for T (CD3), NK (CD56), and B (CD20) cells in a TN (S01b), MPR (P06), and NMPR (P07) patient, respectively. F Quantification of fractions of T, NK, and B cells from the IHC images. One-sided unpaired Wilcoxon test was used