Table 1.
Variant-specific signature amino acids in RSV.
| Lineage | Viral variant (# seq) | N | P | SH | G | M2-2 | L |
|---|---|---|---|---|---|---|---|
| GA2.3.5 | A2016-I (11 seq) |
– | – | – | Ser105Pro + Pro222Gln + Thr249Ile + Tyr273His + Asn318Thr | – | Ser141Pro + Ile234Val |
| A2017-I (14 seq) |
– | – | – | – | – | Asn143Asp + Thr179Ser + Ile1653Val + Lys1661Asn | |
| A2017-II (47 seq) |
– | – | – | K134I + I243S + E262K | – | Asp1731Gly | |
| GB5.0.5a | B2016-I (33 seq) |
Ile65Val | Glu68Asp | Asn64Asp | Thr220Pro | Ile82Met | Ile1716Val + Asn1727Thr + Phe1982Leu |
The haplotypes of amino acid substitutions that characterize the predominant viral variants described in 2016 and 2017 are shown. The genetic lineage, the number of sequences, and the variant-specific signature amino acids in each viral protein (when appropriate) are detailed for each viral variant. The ‘+’ symbol indicates that all the amino acid substitutions together are present in that viral variant.