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Top five L1000 small molecules predicted to downregulate the expression of MEG3
| Rank | CRISPR KO | Up/down | Mean PCC | P-value |
|---|---|---|---|---|
| 1 | PIGW | Down | 0.0353754 | 3.74E−22 |
| 2 | TUBD1 | Down | 0.04438307 | 1.61E−18 |
| 3 | AJUBA | Down | 0.03274345 | 6.60E−18 |
| 4 | IL17RB | Down | 0.05699057 | 1.94E−17 |
| 5 | IL17C | Down | 0.03780365 | 2.14E−17 |
L1000 small molecules are ranked by P-value between MEG3 and the genes in the up gene-set small-molecule signatures.
