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. 2023 Mar 4;6:243. doi: 10.1038/s42003-023-04605-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Head-to-head TM-score comparison of PAthreader with AlphaFold2, pureAF2_orig, pureAF2_notemp, and RoseTTAFold for structure modelling. Each point represents a protein target, and different colors indicate different protein sizes. b The distribution of the TM-score of templates identified by PAthreader and HHsearch. c Comparison of the TM-score of templates by PAthreader and the model obtained using AlphaFold2 on 19 proteins. d Examples of the single-domain protein 7PNO_D and the multi-domain protein 7T4Z_A. The structure superpositions of PAthreader model (blue), AlphaFold2 model (pink), and pureAF2_orig model (green) with the native structure (grey) and template (yellow) are shown.