TABLE 5.

Estimated required number of clusters I, subjects per cluster-period N, periods T , empirical type I error when only setting the first effect to zero and when only setting the second effect to zero (e₁, e₂), empirical power $\overline{\psi }$¸ predicted power $\psi$ obtained from power formula for given effect size ${\delta }^l/{\sigma }_{\delta l}$, within-period and between-period endpoint-specific ICCs (${\rho }_0^l$,${\rho }_1^l$), within-period and between-period between-endpoint ICCs (${\rho }_0^{l{l}^{\prime }}$,${\rho }_1^{l{l}^{\prime }}$), and intra-subject ICC (${\rho }_2^{l{l}^{\prime }}$) assuming a CAC of 0.5 with L = 2 co-primary endpoints.

${\rho }_2^{12}$	(${\rho }_0^1$,${\rho }_1^1$)	(${\rho }_0^2$,${\rho }_1^2$)	(${\rho }_0^{12}$,${\rho }_1^{12}$)	(${\delta }_1/{\sigma }_{\delta 1}$,${\delta }_2/{\sigma }_{\delta 2}$)	I	N	T	(e1, e2)	$\psi$	$\overline{\psi }$
0.2	(0.02, 0.01)	(0.02, 0.01)	(0.01, 0.005)	(0.43, 0.43)	20	13	3	(3.5, 3.0)	84.5	83.0
		(0.10, 0.05)	(0.01, 0.005)	(0.40, 0.38)	12	25	5	(3.8, 4.6)	85.2	86.7
		(0.20, 0.10)	(0.01, 0.005)	(0.39, 0.56)	12	25	4	(3.9, 4.3)	83.6	86.2
	(0.10, 0.05)	(0.02, 0.01)	(0.01, 0.005)	(0.38, 0.33)	12	25	5	(3.5, 4.2)	82.6	85.0
		(0.1, 0.05)	(0.05, 0.025)	(0.49, 0.98)	12	15	4	(4.3, 3.7)	85.6	88.1
		(0.20, 0.10)	(0.05, 0.025)	(0.59, 0.99)	12	20	3	(4.6, 4.9)	84.2	84.7
	(0.20, 0.10)	(0.02, 0.01)	(0.01, 0.005)	(0.47, 0.22)	20	18	5	(5.5, 4.5)	82.2	82.3
		(0.10, 0.05)	(0.05, 0.025)	(0.92, 0.92)	10	12	3	(3.8, 3.5)	84.1	84.8
		(0.20, 0.10)	(0.10, 0.05)	(0.54, 0.81)	12	25	4	(4.9, 3.9)	83.9	85.8
0.5	(0.02, 0.01)	(0.02, 0.01)	(0.01, 0.005)	(0.30, 0.28)	30	10	4	(4.8, 4.7)	84.4	84.1
		(0.10, 0.05)	(0.01, 0.005)	(0.34, 0.88)	16	22	3	(3.3, 4.2)	82.4	81.3
		(0.20, 0.10)	(0.01, 0.005)	(0.42, 0.83)	8	20	5	(1.2, 3.3)	86.3	86.2
	(0.10, 0.05)	(0.02, 0.01)	(0.01, 0.005)	(0.38, 0.55)	21	10	4	(4.8, 5.2)	84.0	84.7
		(0.10, 0.05)	(0.05, 0.025)	(0.52, 0.68)	8	25	5	(3.8, 3.1)	84.8	88.7
		(0.20, 0.10)	(0.05, 0.025)	(0.62, 0.62)	22	8	3	(5.4, 4.9)	83.9	83.9
	(0.20, 0.10)	(0.02, 0.01)	(0.01, 0.005)	(0.84, 0.29)	26	18	3	(4.9, 4.7)	84.7	86.8
		(0.10, 0.05)	(0.05, 0.025)	(0.60, 0.60)	12	16	4	(4.7, 5.3)	85.0	85.8
		(0.20, 0.10)	(0.10, 0.05)	(0.32, 0.84)	24	24	5	(5.1, 4.6)	85.7	86.4
0.8	(0.02, 0.01)	(0.02, 0.01)	(0.01, 0.005)	(0.31, 0.55)	12	16	5	(4.1, 5.0)	84.4	82.6
		(0.10, 0.05)	(0.01, 0.005)	(0.29, 0.57)	30	14	3	(4.0, 4.7)	83.1	84.6
		(0.20, 0.10)	(0.01, 0.005)	(0.20, 0.84)	30	17	4	(4.4, 5.4)	81.4	80.2
	(0.10, 0.05)	(0.02, 0.01)	(0.01, 0.005)	(0.31, 0.62)	20	13	5	(5.1, 3.2)	84.2	83.5
		(0.10, 0.05)	(0.05, 0.025)	(0.82, 0.92)	8	22	3	(2.9, 2.8)	85.2	87.4
		(0.20, 0.10)	(0.05, 0.025)	(0.45, 0.45)	18	18	4	(5.2, 4.6)	83.7	85.4
	(0.20, 0.10)	(0.02, 0.01)	(0.01, 0.005)	(0.99, 0.25)	28	25	3	(5.1, 4.0)	85.6	84.9
		(0.10, 0.05)	(0.05, 0.025)	(0.63, 0.31)	24	17	4	(4.5, 5.6)	84.1	84.6
		(0.20, 0.10)	(0.10, 0.05)	(0.82, 0.82)	8	10	5	(3.2, 2.9)	86.1	89.4