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. 2023 Mar 4;14(3):178. doi: 10.1038/s41419-023-05702-6

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — In U87 (A) and U251 (B) cells, the overexpression and knockdown of TRIM56 upregulated and inhibited CDC42 activation, respectively, with neither affecting total CDC42 expression. C Representative images of Transwell migration assays showing that knockdown of CDC42 or treatment with the CDC42 inhibitor ZCL278 (20 μM) reversed the effect of TRIM56 overexpression on glioma cell migration. D Representative images of Transwell invasion assays showing that knockdown of CDC42 or treatment with the CDC42 inhibitor ZCL278 (20 μM) reversed the effect of TRIM56 overexpression on glioma cell invasion.