FIGURE 1.

Clinical and molecular features of subgroups and subtypes of medulloblastoma. A, Schematic representation that summarizes key clinical features associated with medulloblastoma subgroups. B, C, Clinical features and genetic aberrations in Sonic Hedgehog (SHH) subtypes (B) and group 3 and group 4 subtypes (C) described by Cavalli ¹³ and in the 5th edition of the WHO classification. ¹⁶ The width of each subtype shows the fraction of samples per subtype in the study by Cavalli and the 5th edition of the WHO classification. Subtypes of the WHO classification are defined using MolecularNeuropathology.org (www.molecularneuropathology.org). Illustration of cells demonstrates the stages of cell differentiation in group 3 and group 4 medulloblastoma subtypes (C). RL, rhombic lip; snRNA, small nuclear RNA; TERTp, TERT promoter; SVZ, subventricular zone; VZ, ventricular zone