FIGURE 5.

Treatment with nimesulide enhances the tumor inhibitory effect of CDDP. A, The combination therapy of Nim and CDDP had a stronger antitumor effect than that of CDDP monotherapy (n = 7 in each group). B, In the immunohistochemical analysis of the tumor samples, nimesulide administration decreased F4/80 and CD206 macrophages. C, Nim treatment decreased the ratio of CD206 macrophages. D, The combination therapy of Nim and CDDP prolonged survival after LLC inoculation (n = 11 in the PBS group; n = 10 in the CDDP group; n = 11 in the CDDP+Cel group; n = 9 in the CDDP+Nim group). Nim, nimesulide; CDDP, cisplatin; Cel, celecoxib