Table.
Area under the curve and maximal aggregation inhibition of platelet aggregation after 30 (T30) and 45 (T45) minutes of incubation of clopidogrel with either old or young human liver microsomes.
| Aggregation parameters | T30 |
T45 |
||||
|---|---|---|---|---|---|---|
| Old HLMs | Young HLMs | P | Old HLMs | Young HLMs | P | |
| AUC IPA (%) |
50.6 (17.9-95.5) | 25.9 (11.3-80.6) | .25 | 33.1 (10.9-94.3) | 25.4 (9.32-90.5) | .37 |
| Maximal aggregation IPA (%) |
46.8 (15.4-87.9) | 17 (5.15-67.9) | .11 | 17.9 (7.52-86.1) | 22.7 (3.01-81.4) | .61 |
Results are expressed as median [interquartile ratio].
AUC, area under the curve; HLMs, human liver microsomes; IPA, inhibition of platelet aggregation; IQR, interquartile range.