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. 2023 Mar 6;9:81. doi: 10.1038/s41420-023-01383-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Heatmaps of modulated pathways showing the most differentially expressed genes in DU145 cells treated with 0.5 μM RSL3 + 100 μM FAC for 12 h. B, C The gene expression modulation of HMOX1 and TNFRSF10A, respectively of the ferroptosis and P53 pathway, was confirmed by RT-qPCR analyzes and expressed as % fold change over the not treated (NT) cells (B), while Western blot analysis revealed an increase of Tp53 protein. Gapdh was used for normalization (C). Data are the mean ± SEM of at least 3 experiments (*p < 0.05, **p < 0.01, ***p < 0.001).