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. 2023 Mar 6;9:81. doi: 10.1038/s41420-023-01383-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A In vivo growth of subcutaneous TRAMP-C2 tumors treated i.p. with iron dextran 200 mg/kg twice/week, RSL3 40 mg/kg twice/week or RSL3 + iron and compared with untreated (NT) ones. B Prussian Blue staining (blue dots) and total iron content assay on tumor samples. Data are expressed as % fold change over the not treated (NT). C qPCR of ferroptosis related genes in tumor samples. Data are expressed as % fold change over the not treated (NT). D Immunohistochemistry and quantification of immune populations (CD3, FOXP3 and Ly6G markers) in tumor samples expressed as positive cells/mm². Data are the mean ± SEM of 8–10 tumors/group. ^*p < 0.05, ***p < 0.001, ^#p < 0.0001 refers to each group vs NT group. Scale bar = 100 μm.