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. 2023 Feb 20;14:1125685. doi: 10.3389/fmicb.2023.1125685

Table 3.

FIC index values of AgNPs in combination with antibiotics: ampicillin (AM), kanamycin (K); streptomycin (S), and tetracycline (TE) against bacteria.

Test microorganisms FIC index
AgNPs+AM AgNPs+K AgNPs+S AgNPs+ TE
Escherichia coli ATCC 8739 1 1 0.0625 1
Escherichia coli ATCC 25922 1 1 0.0652 1
Klebsiella pneumoniae ATCC 700603 1 1 0.125 1
Pseudomonas aeruginosa ATCC 10145 0.25 1 0.125 1
Staphylococcus aureus ATCC 6538 1 0.25 1 1
Staphylococcus aureus ATCC 25923 0.125 1 1 1
Listeria monocytogenes PCM 2191 1 0.5 0.5 0.5
Salmonella enterica PCM 2565 1 0.5 1 0.5
Salmonella infantis 1 0.5 1 0.5

FIC values > 2.0 denote antagonistic activity, from 0.5 to 2.0 signify an additive effect, while values < 0.5 specify a synergistic effect of antimicrobials (Ruden et al., 2009).