Table 2.
Circulatory biomarker concentrations in people with coronary heart disease with low or normal skeletal muscle mass (SMM).
| Biomarker | All | Men | Women | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low SMM (n = 14) | Normal SMM (n = 50) | U | ES | p-Value | Low SMM (n = 9) | Normal SMM (n = 47) | U | ES | p-Value | Low SMM (n = 5) | Normal SMM (n = 3) | U | ES | p-Value | |
| Albumin (g/L) | 37.50 (36.00, 39.25) | 38.50 (37.00, 41.00) | 283.00 | 0.14 | 0.274 | 38.00 (36.00, 39.50) | 39.00 (37.00, 41.00) | 170.00 | 0.12 | 0.352 | 37.00 (36.00, 40.00) | 37.00 (36.00, 38.00) | 7.00 | 0.05 | 0.877 |
| Transthyretin (mg/dl) | 29.66 (18.36, 34.08) | 37.87 (28.83, 53.63) | 183.00 | 0.34 | 0.007** | 28.64 (17.51, 34.96) | 37.88 (28.87, 54.55) | 96.00 | 0.34 | 0.010* | 32.07 (22.23, 35.28) | 24.34 (24.08, 50.34) | 7.00 | 0.05 | 0.881 |
| Alanine aminotransferase (U/L) | 20.00 (17.00, 24.00) | 31.00 (21.75, 41.25) | 188.00 | 0.34 | 0.008** | 20.00 (19.50, 24.00) | 32.00 (22.00, 42.00) | 127.50 | 0.25 | 0.061 | 17.00 (14.50, 28.00) | 21.00 (19.00, 24.00) | 3.00 | 0.47 | 0.180 |
| Aspartate aminotransferase (U/L) | 22.25 (18.00, 29.13) | 27.00 (23.00, 34.75) | 221.50 | 0.26 | 0.037* | 24.00 (22.25, 31.50) | 27.50 (23.00, 35.50) | 186.00 | 0.08 | 0.569 | 18.00 (17.25, 20.25) | 25.50 (22.50, 27.00) | 0.00 | 0.79 | 0.025* |
| AST/ALT | 1.17 (0.93, 1.25) | 0.91 (0.69, 1.23) | 255.00 | 0.19 | 0.123 | 1.20 (0.92, 1.31) | 0.86 (0.68, 1.23) | 130.00 | 0.25 | 0.069 | 1.13 (0.76, 1.24) | 1.07 (1.06, 1.42) | 6.00 | 0.16 | 0.655 |
| C-terminal agrin fragment (ng/ml) | 3.89 (3.10, 4.24) | 3.67 (3.11, 4.48) | 335.00 | 0.03 | 0.808 | 4.15 (2.55, 4.53) | 3.63 (3.05, 4.36) | 206.00 | 0.02 | 0.902 | 3.74 (3.37, 4.02) | 4.83 (4.02, 5.25) | 1.00 | 0.69 | 0.053 |
| Hs C-reactive protein (mg/L)a | 2.51 (0.42, 4.33) | 1.19 (0.50, 3.41) | 303.00 | 0.10 | 0.445 | 2.62 (0.58, 4.63) | 1.18 (0.48, 3.41) | 164.00 | 0.14 | 0.289 | 1.87 (0.32, 4.25) | 2.96 (2.17, 8.86) | 4.00 | 0.37 | 0.297 |
Bold values indicate statistical significance (p < 0.05). *p < 0.05 or **p < 0.01 compared to normal SMM group. AST/ALT, alanine aminotransferase/aspartate aminotransferase ratio; ES, effect size; U, U statistic from Mann–Whitney U test. Low SMM was skeletal muscle index <7.0 and <6.0 kg m−2, or appendicular skeletal muscle <25.72 and <19.43%, for men and women, respectively. Values are median (range) where n = 3. All other values are median (interquartile range).
a
Values from a subset of people included in the present study were been reported elsewhere (4).