Figure 10.

Sketch diagram unveils age-related differences between the pathology and treatment of Young POP and Old POP. The main pathology in Old POP was chronic inflammation, while the pathology in in Young POP was mainly related to tissue remodeling. These findings are helpful for improving current prevention and treatment strategies of POP, which suggest the clinicians to adopt different clinical interventions for patients with POP of different ages. For conservative management, Pessaries combinated with anti-inflammatory therapy should be given priority to Old POP, while pelvic floor muscle training can be given priority to Young POP. For surgical techniques, colpocleisis and vaginal prolapse repair combinated with anti-inflammatory therapy are preferred to Old POP, while vaginal prolapse repair could be given priority to Young POP.