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. 2023 Feb 20;14:1084516. doi: 10.3389/fimmu.2023.1084516

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Copyright © 2023 Miao, Wen, Wang, Wen, Cheng, Zhao and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Marker genes and biological process of main cell lineages in Old POP, Young POP and control samples. (A) Fibroblast; (B) Endothelial cells; (C) Macrophage. The endothelial cells, fibroblast and macrophage in Old POP highly expressed inflammation related gene CSF3, CRLF1, LYVE1, separately. The endothelial cells, fibroblast and macrophage in Young POP highly expressed extracellular matrix related gene COL3A1, MMP11, S100A8, separately.