. 2023 Jan 30;12(2):e220461. doi: 10.1530/EC-22-0461
This work is licensed under a Table 3.
Percent change (95% CI) in bone mass density by the systemic immune-inflammation index in pre- and postmenopausal women.
| Variables | n | Total femur | Femur neck | Trochanter | Intertrochanter |
|---|---|---|---|---|---|
| Premenopause | |||||
| Per doubling of SII | 1948 | −0.06 (−0.81, 0.69) | −0.39 (−1.21, 0.44) | −0.40 (−1.28, 0.49) | 0.18 (−0.58, 0.94) |
| SII quartiles | |||||
| Quartile 1 (<376.20) | 487 | Reference | Reference | Reference | Reference |
| Quartile 2 (376.20–514.90) | 487 | 0.08 (−0.06, 1.13) | 0.08 (−1.07, 1.25) | 0.02 (−1.20, 1.27) | 0.18 (−0.87, 1.24) |
| Quartile 3 (515.00–705.50) | 487 | −0.06 (−1.11, 0.99) | −0.21 (−1.36, 0.95) | −0.50 (−1.72, 0.74) | 0.14 (−0.91, 1.20) |
| Quartile 4 (>705.50) | 487 | 0.38 (−0.68, 1.45) | −0.16 (−1.32, 1.10) | 0.12 (−1.12, 1.38) | 0.71 (−0.36, 1.79) |
| P for trend | 0.558 | 0.677 | 0.936 | 0.228 | |
| Postmenopause | |||||
| Per doubling of SII | 2144 | −1.39 (−2.20, −0.57)c | −1.16 (−2.00, −0.31)b | −1.73 (−2.66, −0.78)c | −1.35 (−2.20, −0.50)b |
| SII quartiles | |||||
| Quartile 1 (<337.80) | 536 | Reference | Reference | Reference | Reference |
| Quartile 2 (337.80–463.00) | 537 | −0.48 (−1.70, 0.75) | −0.79 (−2.05, 0.47) | −0.43 (−1.84, 0.99) | −0.38 (−1.64, 0.90) |
| Quartile 3 (463.10–644.00) | 536 | −0.13 (−1.35, 1.11) | 0.16 (−1.11, 1.45) | −0.39 (−1.80, 1.04) | −0.18 (−1.46, 1.11) |
| Quartile 4 (>644.00) | 535 | −1.86 (−3.08, −0.63)b | −1.58 (−2.84, −0.30)a | −2.19 (−3.59, −0.77)b | −1.97 (−3.13, −0.59)b |
| P for trend | 0.008 | 0.068 | 0.005 | 0.009 |
All models were adjusted for age, race, education levels, annual family income, BMI, serum cotinine, physical activity, marital status, calcium intake, smoking status, drinking status, and use of prednisone or cortisone. aP < 0.05, bP < 0.01, cP < 0.001.