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. 2023 Feb 8;30(3):e220221. doi: 10.1530/ERC-22-0221

Figure 1.

Figure 1

MFSD4A-AS1 is upregulated in PTC with lymph node metastasis. (A) MFSD4A-AS1 expression in 59 adjacent normal tissues (ANT) and 503 PTC tissues in the thyroid cancer dataset from TCGA. (B) MFSD4A-AS1 expression in 357 classic PTC, 102 follicular variants of PTC, 36 tall cell variants of PTC and 8 other variants, including 4 diffuse sclerosing variants, 2 cribriform morular variants, 1 columnar cell variant and 1 papillary and follicular variants, in the thyroid cancer dataset from TCGA. (C) Real-time PCR analysis of MFSD4A-AS1 expression in our 48 ANT and 102 PTC tissues without distant metastasis. GAPDH was used as endogenous control. (D) Real-time PCR analysis of MFSD4A-AS1 expression relative to their match ANT in our 48 paired PTC tissues, including 9 T1 PTC tissues without lymphatic metastasis, 7 T2–3 PTC tissues without lymphatic metastasis, 13 T1 PTC tissues with lymphatic metastasis and 19 T2–4 PTC tissues with lymphatic metastasis. GAPDH was used as endogenous control. (E) Real-time PCR analysis of MFSD4A-AS1 expression in our 48 ANT, 47 T1–4 PTC tissues without lymphatic metastasis and 65 T1–4 PTC tissues with lymphatic metastasis. GAPDH was used as endogenous control. n.s. indicates no significant difference. (F) MFSD4A-AS1 expression in 59 ANT, 230 T1–4 PTC tissues without lymphatic metastasis and 225 T1–4 PTC tissues with lymphatic metastasis in the thyroid cancer dataset from TCGA. n.s. indicates no significant difference. (G) Real-time PCR analysis of MFSD4A-AS1 expression in our 32 paired PTC tissues with lymphatic metastasis and the matched adjacent normal tissues. (H) MFSD4A-AS1 expression in 24 paired PTC tissues with lymphatic metastasis and the matched adjacent normal tissues in the PTC dataset from TCGA. (I) Real-time PCR analysis of MFSD4A-AS1 expression in our 48 ANT, 36 T1–2 PTC tissues without lymphatic metastasis and 38 T1–2 PTC tissues with lymphatic metastasis. GAPDH was used as endogenous control. n.s. indicates no significant difference. (J) MFSD4A-AS1 expression in 59 ANT, 164 T1-2 PTC tissues without lymphatic metastasis and 110 T1-2 PTC tissues with lymphatic metastasis in the PTC dataset from TCGA. n.s. indicates no significant difference.