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. 2023 Feb 8;30(3):e220221. doi: 10.1530/ERC-22-0221

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MFSD4A-AS1 promotes lymphatic metastasis and proliferation and migration of HUVECs by upregulating VEGFA and VEGFC. (A) H & E staining analysis of tumors in lymph nodes from the indicated mice group. (B) The number of tumor cells in the tumor areas of lymph nodes from the indicated mice group. *P < 0.05. (C) The effect of silencing VEGFA or VEGFC in MFSD4A-AS1 overexpression PTC cells on tube formation ability of HUVECs in tube formation assay. Each bar represents the mean values ± s.d. of three independent experiments. *P < 0.05. (D) The effect of silencing VEGFA or VEGFC in MFSD4A-AS1 overexpression PTC cells on migration ability of HUVECs in the Transwell assay. Each bar represents the mean values ± s.d. of three independent experiments. *P < 0.05.