Figure 2.

Hypothesis of controlled conversion of pancreatic cells with mixed identity. Conversion of the α/β cell with glucagon transcript (GCG) expression level higher than or similar to insulin transcript (INS) expression level, to the α/β cell with reciprocal expression pattern or to the cell with the β cell-like phenotype, respectively under the influence of molecules interacting with the GABA signalling system of the mixed-identity cell.