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. 2023 Feb 20;11:1136095. doi: 10.3389/fbioe.2023.1136095

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Copyright © 2023 Hedin, Kruse, Vazquez-Uribe and Sommer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical abstract of the implemented biocontainment strategy. (A) Schematic overview of the selection of the biocontainment strain. (B) Yeast cells with disruption of the genes synthesising uracil (URA3), thiamine (THI6), and geranylgeranyl diphosphate synthase (BTS1) can grow in the internal environment containing the essential nutrients and optimal temperature. However, proliferation in external environments lacking the essential nutrients and lower temperatures will be limited.