TABLE 3.
T-CAST results for CCR5-targeting OH-TALEN. Listed are OMTs with >20 hits and the two top scoring NBSs. TALEN combinations: LF, left TALEN arm in forward orientation; LR, left TALEN arm in reverse orientation; RF, right TALEN arm in forward orientation; RR, right TALEN in reverse orientation.
| Scaffold | Group | Chr. | Start | End | Reads | Hits | Combi | Closest gene | Annotation |
|---|---|---|---|---|---|---|---|---|---|
| KKR-ELD | ON | 3 | 46372773 | 46373373 | 2520999 | 8224 | LF.RR | CCR5 | Exon |
| NBS #1 | 3 | 46324767 | 46324967 | 4080 | 17 | LF.RR | CCR2 | Distal Intergenic | |
| NBS #2 | 3 | 12744579 | 12744779 | 5255 | 9 | RF.LR | TMEM40 | Intron | |
| KVR-EAD | ON | 3 | 46372892 | 46373492 | 3068893 | 11259 | LF.RR | CCR5 | Exon |
| OMT #1 | 3 | 136332505 | 136332705 | 9510 | 45 | RF.LR | PCCB | Intron | |
| OMT #2 | 10 | 13181066 | 13181266 | 4331 | 30 | RF.LR | MCM10 | Intron | |
| OMT #3 | 9 | 68584925 | 68585125 | 3821 | 24 | RF.RR | LINC01506 | Intron | |
| NBS #1 | 3 | 45844643 | 45844843 | 9103 | 38 | LF.LR | LZTFL1 | Intron | |
| NBS #2 | 16 | 54414079 | 54414279 | 4671 | 24 | RF.RR | LINC02140 | Distal Intergenic |