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. 2023 Feb 20;14:1078205. doi: 10.3389/fphar.2023.1078205

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Copyright © 2023 Chen, Zhang, Wang, Tan, Lin, Qian, Li and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dapagliflozin improves the glutathione antioxidant system in H/R. (A–C) GSH, GSSG and GSH/GSSG ratio changes in H9C2 cells assayed by a commercial kit (n = 5 per group). (D–F) The protein levels of GPX4 and SLC7A11 were measured by western blotting. Relative densitometry values are shown (n = 5 per group). (G, H) Representative immunofluorescence images of GPX4 and SLC7A11 (scale bar, 100 μm) and quantitative analyses (n = 6 per group).Data are expressed as mean ± SD; One-way ANOVA followed by Tukey’s correction for post hoc multiple comparisons or Dunnett’s multiple comparison tests; #p < 0.05, ##p < 0.01 vs Control group; *p < 0.05, **p < 0.01 vs H/R group.