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. 2023 Feb 20;14:1078205. doi: 10.3389/fphar.2023.1078205

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Copyright © 2023 Chen, Zhang, Wang, Tan, Lin, Qian, Li and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protective effect of dapagliflozin on myocardial I/R injury in vivo. (A) Experimental protocols. (B) Typical ECG segments in the basic state after 30 min of ligation and reperfusion for 2 h (C, D) cTnT and BNP concentrations in each group were detected by ELISA kit (n = 6 per group). (E) Representative transthoracic echocardiography images of the basal state and after reperfusion. (F) Cardiac echocardiography parameters of the experimental rats, including IVS, LVID, LVPW, LVEF (%), LVFS(%), LV mass and volume (n = 5 per group). (G) Representative cross-section images of Evans Blue/TTC double-stained ventricle hearts subjected to I/R in the absence or the presence of Dapa. The red regions represent the area at-risk (TTC stained), the blue regions represent the non-affected areas (Evans Blue stained), and the white regions represent the infarct areas (n = 5 per group). (H) Quantitative analysis of hearts showed a significant reduction in the percentage of white/white + red areas (IA/AAR) of the hearts. (I) Representative images of the left ventricle stained with hematoxylin and eosin (scale bar, 100 μm). Data are expressed as mean ± SD; One-way ANOVA followed by Turkey post hoc tests for TnT, BNP and infarct area analysis, 2-way ANOVA for repeated measures followed by Sidak’s multiple comparison tests for echocardiography parameters analysis; #p < 0.05, ##p < 0.01 vs Sham group; *p < 0.05, **p < 0.01 vs I/R group.