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. 2023 Feb 20;14:1078205. doi: 10.3389/fphar.2023.1078205

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Copyright © 2023 Chen, Zhang, Wang, Tan, Lin, Qian, Li and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dapagliflozin attenuates I/R-mediated ferroptosis. (A–C) The mRNA levels of PTGS2, ACSL4 and NCOA4 were measured by qPCR (n = 6 per group). (D) Ferrous iron levels in myocardial tissue were determined by a commercial kit (n = 4 per group). (E–H) Myocardial tissue protein levels of PTGS2, SLC7A11 and GPX4 were measured by western blotting (n = 6 per group).; Data are expressed as mean ± SD; One-way ANOVA followed by Tukey’s correction for post hoc multiple comparisons or Dunnett’s multiple comparison tests; #p < 0.05, ##p < 0.01 vs Sham group; *p < 0.05, **p < 0.01 vs I/R group.