Table 1.

Summary parameters for alternative PRSs.^a

	No of SNPs	Mean controls	Mean cases	SD controls	SD cases	LogOR per 1 SD	95%CI	α GLM b	95%CI	α RL c	95%CI	Ratio (αRL:LogOR per 1 SD)	Predicted αRL
BCAC PRS313	313	−0.424	−0.114	0.611	0.619	0.497	0.476 – 0.519	0.397	0.378 – 0.415	0.501	0.485 – 0.517	1.006	0.501
BRIDGES	306	−0.422	−0.114	0.608	0.615	0.495	0.474 – 0.517	0.394	0.376 – 0.413	0.498	0.481 – 0.512	1.005	0.499
PERSPECTIVE	295	−0.448	−0.147	0.599	0.609	0.489	0.468 – 0.511	0.389	0.371 – 0.408	0.492	0.476 – 0.507	1.005	0.492
EASTGLH	303	−0.407	−0.100	0.606	0.613	0.494	0.472 – 0.516	0.394	0.375 – 0.412	0.497	0.481 – 0.513	1.005	0.497
PRISMA	268	0.322	0.575	0.558	0.565	0.446	0.424 – 0.467	0.358	0.339 – 0.376	0.451	0.436 – 0.468	1.013	0.448
eMERGE	308	−0.456	−0.150	0.608	0.616	0.495	0.473 – 0.516	0.394	0.376 – 0.413	0.498	0.483 – 0.513	1.007	0.498
DBDS299	299	−0.508	−0.211	0.596	0.605	0.486	0.465 – 0.508	0.387	0.369 – 0.406	0.490	0.474 – 0.507	1.007	0.489
BCAC PRS77	77	−0.892	−0.703	0.449	0.460	0.394	0.373 – 0.415	0.310	0.292 – 0.328	0.396	0.381 – 0.412	1.005	0.397
BCAC PRS3820	3820	−0.445	−0.199	0.460	0.463	0.518	0.496 – 0.540	0.412	0.393 – 0.431	0.516	0.501 – 0.533	0.996	0.521
WISDOM75	74	−1.057	−0.835	0.567	0.573	0.360	0.338 – 0.381	0.281	0.263 – 0.299	0.360	0.344 – 0.373	1.000	0.362
WISDOM128	126	−0.180	0.040	0.464	0.478	0.449	0.427 – 0.470	0.355	0.337 – 0.374	0.452	0.437 – 0.470	1.007	0.452
PRS constructed as above but excluding SNPs correlated with CHEK2*1100delC
BCAC PRS311	311	−0.092	0.217	0.609	0.618	0.496	0.474 – 0.518	0.395	0.377 – 0.414	0.498	0.483 – 0.512	1.005	0.499
BRIDGES	305	−0.428	−0.121	0.607	0.615	0.495	0.473 – 0.516	0.394	0.375 – 0.412	0.497	0.481 – 0.511	1.005	0.498
PERSPECTIVE	293	−0.116	0.183	0.598	0.607	0.488	0.466 – 0.510	0.388	0.369 – 0.406	0.490	0.474 – 0.505	1.004	0.491
EASTGLH	301	−0.075	0.230	0.604	0.612	0.492	0.471 – 0.514	0.392	0.374 – 0.411	0.495	0.479 – 0.510	1.004	0.496
eMERGE	306	−0.124	0.181	0.606	0.614	0.493	0.471 – 0.515	0.393	0.374 – 0.411	0.496	0.481 – 0.511	1.006	0.496
DBDS297	297	−0.177	0.119	0.594	0.603	0.485	0.463 – 0.506	0.386	0.367 – 0.404	0.487	0.472 – 0.502	1.006	0.488
BCAC PRS3818	3818	−0.227	0.017	0.459	0.462	0.517	0.495 – 0.539	0.411	0.392 – 0.430	0.514	0.501 – 0.535	0.995	0.520

SNP, single nucleotide polymorphism; SD, standard deviation, OR; Odds Ratio; CI, Confidence Interval; GLM, Generalized Linear Model; RL, Retrospective Likelihood.

^aResults based on 22767 controls and 16151 cases in the prospective and validation sets from Mavaddat et al. (3). European women with known age and age less than 80;

^b α _GLM is based on logistic regression adjusted for country in which studies were conducted and 10 principal components.

^c α _RL is based on retrospective likelihood method as described in Materials and Methods and Supplementary Methods.

BRIDGES includes 22_29203724_C_T but not 22_29551872_A_G.

BCAC PRS313, BCAC 3820, eMERGE, DBDS299, EASTGLH and PERSPECTIVE include both 22_29203724_C_T and 22_29551872_A_G.

PRISMA has neither 22_29551872_A_G nor 22_29203724_C_T and includes 37 surrogates.