Fig. 5.

Multi-dose therapeutic efficiency of Lipo@GB-DHA in MCAO rats by i.v. Lipo@GB-DHA after 6 h of reperfusion. (A) Schematic illustration of treatment regimens. (B) Representative T2W MRI images of MCAO rats injected with different formulations at Day 0 and Day 6. (C-D) Modified neurological severity score (mNSS) and body weight of MCAO rats with different drugs during the experiment. (E-F) The quantitative data of shaded areas in brains of MCAO rats at day 0 (E) and day 6 (F). (G) Representative images of TUNEL and NeuN staining in the ischemic penumbra (Scale bars, 200 μm/20 μm). Data in (C-D, E-F) were expressed as mean ± SD (n = 4/5). *P < 0.05,**P < 0.01, ***P < 0.001.