Table 3.

Multivariate analysis exploring clinical and ultrasonographic variables and outcomes

	aOR (95%CI)	p value
Outcome - weaning success
RF-CSA ≥ 1.80cm2 (reference: yes)*	5.85 (1.22 - 28)	0.027
DEx ≥ 1.25cm (reference: yes)*	2.11 (0.52 - 8.54)	0.295
MIP†	1.06 (1.01 - 1.11)	0.015
SOFA†	0.67 (0.5-0.9)	0.008
SAPS III†	0.96 (0.91 - 1.02)	0.162
Active infection * (reference: yes)	0.07 (0 - 1.14)	0.062
Outcome - weaning success
RF-CSA ≥ 1.80cm2 plus DEx ≥ 1.25cm (reference: yes)*	20.81 (2.38 - 182.28)	0.006
MIP†	1.07 (1.01 - 1.12)	0.011
SOFA†	0.63 (0.46 - 0.86)	0.003
SAPS III†	0.95 (0.9 - 1.02)	0.139
Days on MV pre weaning (≤ 21 days)*	3.66 (0.62 - 21.49)	0.151
Active infection*	0.08 (0 - 1.51)	0.091
Outcome - ICU mortality
RF-CSA ≥ 1.80cm2 (reference: yes)*	0.32 (0.08 - 1.26)	0.096
DEx ≥ 1.25cm (reference: yes)*	1.35 (0.31 - 5.76)	0.687
MIP†	0.95 (0.9 - 0.99)	0.005
SOFA†	1.78 (1.3 - 2.44)	<0.001
SAPS III†	1.04 (0.98 - 1.1)	0.142
Outcome - ICU mortality
RF-CSA ≥ 1.80cm2 plus DEx ≥ 1.25cm (reference: yes)*	0.19 (0.03 - 1.08)	0.061
MIP†	0.94 (0.9 - 0.99)	0.014
SOFA†	1.05 (0.99 - 1.11)	0.104
Days on MV pre weaning (< 21 days)*	0.28 (0.05 - 1.51)	0.139
Outcome - palliative care
RF-CSA ≥ 1.80cm2 (reference: yes)*	0.59 (0.16 - 2.14)	0.427
DEx ≥ 1.25cm (reference: yes)*	0.18 (0.04 - 0.76)	0.019
MIP†	0.98 (0.95 - 1.01)	0.185
SOFA†	1.38 (1.08 - 1.76)	0.01
SAPS III†	1.07 (1.01 - 1.13)	0.019
Outcome - palliative care
RF-CSA ≥ 1.80cm2 plus DEx ≥ 1.25cm (reference: yes)*	0.2 (0.05 - 0.84)	0.027
SOFA†	1.26 (1.05 - 1.51)	0.015
SAPS III†	1.06 (1.01 - 1.11)	0.013

aOR - adjusted odds ratio; 95%CI - 95% confidence interval; RF-CSA - rectus femoris cross-sectional area; DEx - diaphragmatic excursion; MIP - maximal inspiratory pressure; SOFA - Sequential Organ Failure Assessment; SAPS III - Simplified Acute Physiology Score III; ICU - intensive care unit; MV - mechanical ventilation.

^*Categorical variables in the model; † continuous variables in the model.