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. 2023 Mar 6;15:45. doi: 10.1186/s13195-023-01183-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Cognitive composites over time by progressor status: Individual time profiles and LOESS estimates. APCC, Alzheimer’s Prevention Initiative Preclinical Composite Cognitive; LOESS, locally estimated scatterplot smoothing; MCI, mild cognitive impairment; NACC, National Alzheimer’s Coordinating Center; PACC, Preclinical Alzheimer Cognitive Composite; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; ROS/MAP/MARS, Religious Orders Study/Memory and Aging Project/Minority Aging Research Study. Trajectories are anchored at the time of diagnosis for progressors to dementia and aligned by the median age of progressors at the time of diagnosis of dementia for progressors to MCI and for non-progressors to MCI/dementia