Table 4.

Endpoint characteristics for two different age distributions within the selected age range

HR	Age distribution 3:2:1			Age distribution 1:2:2
	Median TTE, years	Event risk at year 5	Effect size of APCC change from BL to year 5	Median TTE, years	Event risk at year 5	Effect size of APCC change from BL to year 5
0.60	10.705	0.228	0.2209	9.095	0.269	0.2319
0.65	10.045	0.243	0.1916	8.830	0.286	0.2008
0.67	10.000	0.248	0.1827	8.500	0.293	0.1860
0.70	9.640	0.258	0.1752	8.500	0.304	0.1765
0.75	9.230	0.273	0.1364	8.000	0.321	0.1325
1.00	7.500	0.343	0.0000	6.500	0.399	0.0000

APCC Alzheimer’s Prevention Initiative Preclinical Composite Cognitive, BL baseline, HR hazard ratio, TTE time to event