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. 2023 Mar 6;21:176. doi: 10.1186/s12967-023-04029-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Composition of immune infiltrating cells in association with three hub genes in the cohort retrieved from TCGA. A: Percentage of immune cells between the normal group and the READ patients. Green: the normal control group; Purple: the READ group. B: Interaction analysis among 22 different immune cells in READ patients (* represented P < 0.05, ** represented P < 0.01 and *** represented P < 0.001). C. Comparisons of immune cells between in the normal control group and READ tissue group (* represented P < 0.05, ** represented P < 0.01 and *** represented P < 0.001 between the two group). D. Bubble map for the correlations between three hub genes (ALG 10, PLAGL2 and ZNF337) and tumor immune infiltration cells (* represented P < 0.05, ** represented P < 0.01; The bigger the circle, the closer the P - value was to zero; The redder the color, the stronger the positive correlation; The deeper of the purple color, the stronger the negative correlation)