FIG. 3.

Developmental lacZ expression in various tissues of Sox8-deficient embryos. Higher magnifications of X-Gal-stained transverse (A and C) and sagittal (B, D, E, and F) vibratome sections of homozygous embryos at 15.5 dpc (A to D) and 16.5 dpc (E and F), showing nasal epithelium (A), pituitary (B), eye (C), trigeminus (D), humerus (E), and cochlea (F), are presented. Abbreviations: a, pars anterior of pituitary; b, bone; drg, dorsal root ganglia; cart, hyaline cartilage; hyp ch, hypertrophic chondrocytes; i, pars intermedia of pituitary; l, lens; m, muscle; n, pars nervosa of the pituitary; np, nasal pit; oe, olfactory epithelium; on; optic nerve; om, ocular muscle; p ch, proliferating chondrocytes; pe, pigment epithelium; r, retina; sc, spinal cord; tr, trigeminal nerve.