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. 2023 Mar 6;15:36. doi: 10.1186/s13098-023-01004-1

Table 3.

Threshold effect analysis of S100A11 on metabolic markers by using two-piecewise linear regression, stratified by glucose tolerance

Inflection points of HbA1c Inflection points of FPG Inflection points of 0.5hPPG Inflection points of FPI
β (95%CI) P β (95%CI) P β (95%CI) P β (95%CI) P
Normal  > 5.78 0.26 (0.04, 0.47) 0.0316  > 4.19 0.16 (− 0.01, 0.32) 0.0741  > 4.19  − 0.51 (− 0.98, − 0.03) 0.0482  > 2.76 2.43 (− 4.47, 9.33) 0.4965
 ≤ 5.78  − 0.43 (− 0.85, − 0.02) 0.0538  ≤ 4.19  − 0.06 (− 0.20, 0.08) 0.4184  ≤ 4.19 0.15 (− 0.26, 0.55) 0.4804  ≤ 2.76  − 0.71 (− 2.69, 1.27) 0.4906
IGT  > 8.74  − 0.11 (− 0.22, 0.01) 0.1010  > 8.29 0.06 (− 0.08, 0.21) 0.3874  > 3.63  − 10.72 (− 23.94, 2.50) 0.1329  > 6.48 4.07 (0.56, 7.58) 0.0383
 ≤ 8.74 3.41 (− 0.03, 6.85) 0.0708  ≤ 8.29 0.06 (− 0.08, 0.21) 0.3874  ≤ 3.63 0.40 (− 0.05, 0.85) 0.1028  ≤ 6.48  − 4.29 (− 8.85, 0.28) 0.0856
Diabetes  > 12.4 0.11 (− 0.05, 0.28) 0.1979  > 12.4  − 0.09 (− 0.26, 0.08) 0.3082  > 3.97 2.36 (− 1.82, 6.55) 0.2783  > 4.1 8.67 (1.79, 15.56) 0.0201
 ≤ 12.4  − 0.90 (− 1.63, − 0.18) 0.0213  ≤ 12.4 0.88 (0.15, 1.62) 0.0262  ≤ 3.97  − 0.10 (− 0.39, 0.20) 0.5325  ≤ 4.1  − 0.36 (− 0.97, 0.25) 0.2588
Inflection points of HOMA-IR Inflection points of ISI (the liver) Inflection points of ISI (the body) Inflection points of CIR
β (95%CI) P β (95%CI) P β (95%CI) P β (95%CI) P
Normal  > 2.76 0.88 (− 0.66, 2.42) 0.2750  > 4.19  − 1.06 (− 4.13, 2.01) 0.5061  > 5.08  − 0.30 (− 0.81, 0.20) 0.2520  > 7.44 33.88 (− 0.75, 68.51) 0.0677
 ≤ 2.76  − 0.21 (− 0.68, 0.25) 0.3770  ≤ 4.19 1.22 (− 1.35, 3.78) 0.3623  ≤ 5.08 0.14 (− 0.55, 0.82) 0.7013  ≤ 7.44  − 118.09 (− 369.04, 132.86) 0.3659
IGT  > 6.48 1.31 (0.28, 2.33) 0.0235  > 5.49 2.57 (− 1.73, 6.87) 0.2591  > 3.63  − 12.94 (− 24.64, − 1.25) 0.0437  > 5.49  − 58.38 (− 97.32, − 19.44) 0.0096
 ≤ 6.48  − 1.32 (− 2.67, 0.02) 0.0718  ≤ 5.49  − 2.84 (− 5.52, − 0.17) 0.0532  ≤ 3.63 0.05 (− 0.37, 0.47) 0.8173  ≤ 5.49 5.74 (− 18.22, 29.71) 0.6448
Diabetes  > 9.71  − 0.17 (− 0.63, 0.29) 0.4725  > 3.33  − 20.05 (− 38.24, − 1.86) 0.0395  > 5.24 1.80 (− 0.86, 4.45) 0.1945  > 4.1  − 22.54 (− 57.37, 12.29) 0.2152
 ≤ 9.71 1.03 (0.15, 1.91) 0.0300  ≤ 3.33 0.10 (− 0.30, 0.51) 0.6208  ≤ 5.24  − 0.88 (− 1.62, − 0.15) 0.0256  ≤ 4.1 1.36 (− 1.63, 4.35) 0.3809

Effect: HbA1c, FPG, FPI, 0.5hPPG, HOMA-IR, ISI (the liver), ISI (the body), CIR; cause: S100A11

Adjusted: gender, age, BMI, WHR, 0.5hPPG/0.5hPPI/HbA1c/FPG/FPI